Substrate Specificity in the Fungal Metabolism of Prenylated Flavonoids
نویسندگان
چکیده
The prenylated flavonoids, topazolin [5,7,4'-trihydroxy-3-methoxy-6-(3,3-dimethylaIlyl)flavone], piscerythrone [5,7,2',4'-tetrahydroxy-5'-methoxy-3'-(3,3-dimethylallyl)isoflavone] and piscidone [5,7,4',5'-tetrahydroxy-2'-methoxy-6'-(3,3-dimethylallyl)isoflavone] were meta bolized by Aspergillus flavus and Botrytis cinerea to give a variety of products. Topazolin and piscerythrone were converted by both fungi to compounds similar to those previously ob tained from luteone (6-prenyl) and licoisoflavone A (3'-prenyl) respectively. The 6'-prenylated isoflavone piscidone was metabolized only by B. cinerea to give the corresponding dihydropyrano-isoflavone as a major product. Neither fungus was found to metabolize the 8-prenylated pyranoflavanonol lupinifolinol.
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